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Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2
- Source :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry. 57:140-145
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Cannabinoid and PPAR receptors show well established interactions in a set of physiological effects. Regarding the seizure-modulating properties of both classes of receptors, the present study aimed to evaluate the roles of the PPAR-gamma, PPAR-alpha and CB1 receptors on the anticonvulsant effects of WIN 55,212-2 (WIN, a non selective cannabinoid agonist). The clonic seizure thresholds after intravenous administration of pentylenetetrazole (PTZ) were assessed in mice weighing 23-30 g. WIN increased the seizure threshold dose dependently. Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially. On the other hand PPARα antagonist reduced the anticonvulsant effects of WIN significantly. Finally the combination of CB1 antagonist and PPARα antagonist could completely block the anticonvulsant properties of WIN. Taken together, these results show for the first time that a functional interaction exists between cannabinoid and PPAR receptors in the modulation of seizure susceptibility.
- Subjects :
- Male
Agonist
Cannabinoid receptor
medicine.drug_class
Morpholines
medicine.medical_treatment
Peroxisome Proliferator-Activated Receptors
Naphthalenes
Pharmacology
Mice
Piperidines
Receptor, Cannabinoid, CB1
Seizures
medicine
Animals
Anilides
Drug Interactions
Receptor
WIN 55,212-2
Cannabinoid Receptor Antagonists
Oxazoles
Biological Psychiatry
Dose-Response Relationship, Drug
Pioglitazone
Seizure threshold
Chemistry
Antagonist
Benzoxazines
Disease Models, Animal
Anticonvulsant
Pentylenetetrazole
Pyrazoles
Tyrosine
Anticonvulsants
Thiazolidinediones
lipids (amino acids, peptides, and proteins)
Cannabinoid
psychological phenomena and processes
medicine.drug
Subjects
Details
- ISSN :
- 02785846
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....21f969eba5e36d9680b7bb4f437cea00