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Reproducibility of Macular Thickness Measurements in Eyes Affected by Dry Age-Related Macular Degeneration From Two Different SD-OCT Instruments
- Source :
- Ophthalmic surgery, lasersimaging retina. 49(6)
- Publication Year :
- 2017
-
Abstract
- BACKGROUND AND OBJECTIVE: To compare macular thickness measurement algorithms of two different spectral-domain optical coherence tomography (SD-OCT) devices in eyes affected by dry age-related macular degeneration (AMD). PATIENTS AND METHODS: Patients with dry AMD and healthy volunteers from the retina clinic of the Doheny Eye Center – UCLA were imaged using two different SD-OCT devices: the RS-3000 Advance (Nidek, Padova, Italy) and the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). All patients had been previously diagnosed with drusen or geographic atrophy due to AMD. The commercial instrument software was used to generate the macular retinal thickness measurements, and measurements were compared between devices. RESULTS: Eighty-five diseased eyes from 49 patients and 16 healthy control eyes from eight normal volunteers were included in this study. The macular thickness measurements generated by the two instruments in eyes with AMD differed significantly in mean retinal thickness in the foveal center subfield (257.34 μm ± 51.72 μm using the Nidek OCT vs. 238.20 μm ± 51.89 μm using the Cirrus OCT; P < .001). The mean difference in macular thickness between the two devices was 19.14 μm ± 5.84 μm for diseased eyes and 17.06 μm ± 5.28 μm in normal control eyes, and this was not statistically different between the two groups ( P > .05). The macular thickness measurements in diseased eyes, as evaluated by the two different instruments, however, showed excellent correlation (r = 0.99; P < .001), with an intraclass correlation coefficient of 0.99 (95% confidence interval, 0.98–0.99). Post hoc evaluation of cases with larger differences also showed differences in foveal center selection and variabilities in boundary selection with specific pathology. CONCLUSION: Macular thickness measurements provided by the Nidek and Cirrus OCT instruments in eyes with dry AMD are highly correlated but show a consistent difference, which may allow the use of a standard correction factor to be applied to better interrelate measurements between the devices. [ Ophthalmic Surg Lasers Imaging Retina . 2018;49:410–415.]
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
genetic structures
Intraclass correlation
Drusen
03 medical and health sciences
chemistry.chemical_compound
Macular Degeneration
Young Adult
0302 clinical medicine
Optical coherence tomography
Ophthalmology
Geographic Atrophy
medicine
Humans
Macula Lutea
Aged
Aged, 80 and over
Reproducibility
Retina
medicine.diagnostic_test
business.industry
Reproducibility of Results
Retinal
Macular degeneration
Middle Aged
medicine.disease
eye diseases
030104 developmental biology
medicine.anatomical_structure
chemistry
Case-Control Studies
030221 ophthalmology & optometry
Cirrus
Female
sense organs
business
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 23258179
- Volume :
- 49
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Ophthalmic surgery, lasersimaging retina
- Accession number :
- edsair.doi.dedup.....21f765b4050e645748a8025fe8d51443