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Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients
- Source :
- Annals of Surgical Oncology. 23:2883-2888
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Metadherin (MTDH) is widely recognized as a promising molecular marker for tumor recurrence and poor survival in many cancers. By multiple pathways, MTDH promotes oncogenesis, metastasis, and chemoresistance. This study investigated the role of MTDH in papillary thyroid carcinoma (PTC) to determine its potential association with aggressive clinical and pathologic features, including its relation in tumors harboring a BRAF V600E mutation. Expression of MTDH was assessed by immunohistochemistry in 96 cases of PTC, including primary thyroid malignancies and lymph node metastases. The status of BRAF V600E mutation was determined by real-time polymerase chain reaction. Overexpression of MTDH was observed in 26 % (23/88) of primary PTC cases. High-intensity staining was observed in 75 % (6/8) of lymph nodes with metastatic PTC and moderate staining in 25 % (2/8) of cases. Normal adjacent thyroid tissue and benign thyroid controls were found to have significantly lower MTDH expression than cancer tissue (p
- Subjects :
- Adult
Male
Proto-Oncogene Proteins B-raf
0301 basic medicine
Oncology
medicine.medical_specialty
endocrine system diseases
Thyroid Gland
Papillary thyroid cancer
Metastasis
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Humans
Neoplasm Invasiveness
Thyroid Neoplasms
Lymph node
business.industry
Thyroid
Membrane Proteins
RNA-Binding Proteins
Cancer
MTDH
Middle Aged
medicine.disease
Carcinoma, Papillary
030104 developmental biology
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Cancer research
Female
Surgery
business
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....21cc096b1fd44914b37dac3c4e831485