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Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation
- Source :
- Current Gastroenterology Reports
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients. Long-term follow-up studies show that today meconium ileus is not a risk factor for impaired nutritional status, pulmonary function, or survival. DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored. Diagnosis of DIOS is based on suggestive symptoms, with a right lower quadrant mass confirmed on abdominal radiography, whereas symptoms of constipation are milder and of longer standing. In DIOS, early aggressive laxative treatment with oral laxatives (polyethylene glycol) or intestinal lavage with balanced osmotic electrolyte solution and rehydration is required, which now makes the need for surgical interventions rare. Constipation can generally be well controlled with polyethylene glycol maintenance treatment.
- Subjects :
- Meconium
Spirometry
medicine.medical_specialty
Pulmonary function
Constipation
Cystic Fibrosis
Survival
Ileus
medicine.medical_treatment
Laxative
Meconium Ileus
Cystic fibrosis
Gastroenterology
Article
Abdominal radiography
Distal intestinal obstruction syndrome
Cystic fibrosis transmembrane regulator
Nutritional status
Meconium ileus equivalent
Risk Factors
Internal medicine
medicine
Humans
Meconium ileus
Fat malabsorption
Body mass index
Coefficient of fat absorption
medicine.diagnostic_test
Height
business.industry
General Medicine
Weight
medicine.disease
Steatorrhea
Modifier genes
Surgery
Anthropometric variables
medicine.symptom
business
Intestinal Obstruction
Subjects
Details
- ISSN :
- 1534312X and 15228037
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Current Gastroenterology Reports
- Accession number :
- edsair.doi.dedup.....21b66dbcd7cd39acf3e1ce53150e78ec