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Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation

Authors :
Cornelis K. van der Ent
Roderick H. J. Houwen
Hubert P. J. van der Doef
Freddy T. M. Kokke
Source :
Current Gastroenterology Reports
Publication Year :
2011
Publisher :
Springer Science and Business Media LLC, 2011.

Abstract

Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients. Long-term follow-up studies show that today meconium ileus is not a risk factor for impaired nutritional status, pulmonary function, or survival. DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored. Diagnosis of DIOS is based on suggestive symptoms, with a right lower quadrant mass confirmed on abdominal radiography, whereas symptoms of constipation are milder and of longer standing. In DIOS, early aggressive laxative treatment with oral laxatives (polyethylene glycol) or intestinal lavage with balanced osmotic electrolyte solution and rehydration is required, which now makes the need for surgical interventions rare. Constipation can generally be well controlled with polyethylene glycol maintenance treatment.

Details

ISSN :
1534312X and 15228037
Volume :
13
Database :
OpenAIRE
Journal :
Current Gastroenterology Reports
Accession number :
edsair.doi.dedup.....21b66dbcd7cd39acf3e1ce53150e78ec