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A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum
- Source :
- Trends in parasitology. 31(8)
- Publication Year :
- 2015
-
Abstract
- The spread of resistance of malaria infections to artemisinin is a major concern for the future. The Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K) may be a potential target of artemisinin and effector of resistance. This could be mediated by the Kelch13 protein, the molecular marker of resistance that modulates PfPI3K ubiquitination.
- Subjects :
- Effector
Mechanism (biology)
Artemisinin resistance
Plasmodium falciparum
Drug Resistance
Protozoan Proteins
Drug resistance
Biology
medicine.disease
biology.organism_classification
Virology
Artemisinins
Antimalarials
Phosphatidylinositol 3-Kinases
Infectious Diseases
parasitic diseases
medicine
Humans
Parasitology
Artemisinin
Malaria
Asia, Southeastern
medicine.drug
Subjects
Details
- ISSN :
- 14715007
- Volume :
- 31
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Trends in parasitology
- Accession number :
- edsair.doi.dedup.....219ca13b2d8a0a3212883fef7db24246