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Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2000
- Publisher :
- Rockefeller University Press, 2000.
-
Abstract
- Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory lesions in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. Monocyte chemoattractant protein (MCP)-1, a potent agonist for directed monocyte migration, has been implicated in the pathogenesis of EAE. Here we report that deficiency in CC chemokine receptor (CCR)2, the receptor for MCP-1, confers resistance to EAE induced with a peptide derived from myelin oligodendrocyte glycoprotein peptide 35–55 (MOGp35–55). CCR2−/− mice immunized with MOGp35–55 failed to develop mononuclear cell inflammatory infiltrates in the CNS and failed to increase CNS levels of the chemokines RANTES (regulated on activation, normal T cell expressed and secreted), MCP-1, and interferon (IFN)-inducible protein 10 (IP-10) as well the chemokine receptors CCR1, CCR2, and CCR5. Additionally, T cells from CCR2−/− immunized mice showed decreased antigen-induced proliferation and production of IFN-γ compared with wild-type immunized controls, suggesting that CCR2 enhances the T helper cell type 1 immune response in EAE. These data indicate that CCR2 plays a necessary and nonredundant role in the pathogenesis of EAE.
- Subjects :
- Central Nervous System
CCR1
CCR2
Chemokine
Encephalomyelitis, Autoimmune, Experimental
Receptors, CCR5
Receptors, CCR2
T-Lymphocytes
animal diseases
Immunology
chemokines
C-C chemokine receptor type 6
Biology
Myelin oligodendrocyte glycoprotein
Mice
03 medical and health sciences
Chemokine receptor
0302 clinical medicine
medicine
Animals
Immunology and Allergy
Chemokine CCL5
Chemokine CCL2
030304 developmental biology
Mice, Knockout
receptors, chemokine
0303 health sciences
Experimental autoimmune encephalomyelitis
Brief Definitive Report
medicine.disease
Immunity, Innate
cytokines
macrophages
3. Good health
Chemokine CXCL10
Mice, Inbred C57BL
Myelin-Associated Glycoprotein
biology.protein
encephalomyelitis
Myelin-Oligodendrocyte Glycoprotein
CC chemokine receptors
Chemokines, CXC
Myelin Proteins
030215 immunology
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 192
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....219ae164b932b7dcc0537faa4b5ecbac