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Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes
- Publication Year :
- 2014
- Publisher :
- Wiley-VCH Verlag, 2014.
-
Abstract
- The dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes proceeds with high yields and regioselectivities under Rh(III) catalysis. These reactions are successful using Cu(OAc)2 or air as the stoichiometric oxidant, and provide spirocyclic enones, the basic ring system of which appears in several natural products. Application of this process to the preparation of a highly functionalized tetracycle is also demonstrated.
- Subjects :
- chemistry.chemical_classification
Annulation
Molecular Structure
Enyne
Chemistry
Organic Chemistry
chemistry.chemical_element
Alkyne
General Chemistry
Oxidative phosphorylation
Ring (chemistry)
Combinatorial chemistry
Catalysis
Rhodium
chemistry.chemical_compound
Cyclization
Alkynes
Phenol
Organic chemistry
Oxidation-Reduction
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2194134ebf18111593a6710db5239916