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Enabling modular dosage form concepts for individualized multidrug therapy: Expanding the design window for poorly water-soluble drugs
- Source :
- International Journal of Pharmaceutics. 602:120625
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Multidrug dosage forms (aka combination dosage forms, polypills, etc.) create value for patients through reduced pill burdens and simplified administration to improve adherence to therapy. Enhanced flexibility of multidrug dosage forms would provide further opportunities to better match emerging needs for individualized therapy. Through modular dosage form concepts, one approach to satisfy these needs is to adapt multidrug dosage forms to a wider variety of drugs, each with a variety of doses and release profiles. This study investigates and technically explores design requirements for extending the capability of modular multidrug dosage form concepts towards individualization. This builds on our recent demonstration of independent tailoring of dose and drug release, which is here extended towards poorly water-soluble drugs. The challenging design requirement of carrying higher drug loads in smaller volumes to accommodate multiple drugs at their clinical dose is here met regarding dose and release performance. With a modular concept, we demonstrate high precision (
- Subjects :
- Drug
Computer science
Drug Compounding
media_common.quotation_subject
Pharmaceutical Science
Leprostatic Agents
02 engineering and technology
Kollidon VA64
030226 pharmacology & pharmacy
Dosage form
03 medical and health sciences
0302 clinical medicine
Humans
AKA
media_common
Flexibility (engineering)
Felodipine
business.industry
Water
Modular design
021001 nanoscience & nanotechnology
Reliability engineering
Water soluble
Pharmaceutical Preparations
Solubility
Drug release
Drug Therapy, Combination
0210 nano-technology
business
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 602
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....21907c14798052c2ea5ec103771e25ff