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Serum perfluoroalkyl substances, vaccine responses, and morbidity in a cohort of guinea-bissau children
- Source :
- Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum perfluoroalkyl substances, vaccine responses, and morbidity in a cohort of guinea-bissau children ', Environmental Health Perspectives, vol. 128, no. 8, pp. 087002 . https://doi.org/10.1289/EHP6517, Environmental Health Perspectives, Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children ', Environmental Health Perspectives, vol. 128, no. 8, 087002 . https://doi.org/10.1289/EHP6517, Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum perfluoroalkyl substances, vaccine responses, and morbidity in a cohort of guinea-bissau children ', Environmental Health Perspectives, vol. 128, no. 8, 087002 . https://doi.org/10.1289/EHP6517
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Perfluoroalkyl substances (PFAS) are a group of widely used persistent chemicals with suspected immunotoxic effects. OBJECTIVES: The present study aimed to examine the association between infant PFAS exposure and antibody responses to measles vaccination as well as morbidity in a low-income country. METHODS: In a randomized controlled trial, children from Guinea-Bissau, West Africa, were followed from inclusion (4-7 months of age) through 2 years of age. Half the children received two measles vaccinations (at inclusion and at 9 months of age), and the other half received only one (at 9 months of age). In a subset of 237 children, six PFAS were quantified in serum at inclusion, and measles antibody concentrations were assessed at inclusion and at approximately 9 months and 2 years of age. At inclusion and at the 9-month visit, mothers were interviewed about infant morbidity. RESULTS: All but one child had detectable serum concentrations of all six PFAS, although levels were lower than seen elsewhere. A doubling in perfluorooctane sulfonic acid (PFOS) and perfluorodecanoic acid (PFDA) were associated with 21% (95% CI: 2, 37%) and 25% (95% CI: 1, 43%), respectively, lower measles antibody concentrations at the 9-month visit among the children who had received a measles vaccine at inclusion. Elevated serum PFAS concentrations were also associated with reduced prevaccination measles antibody concentrations and increased morbidity. DISCUSSION: The present study documents that PFAS exposure has reached West Africa and that infants show PFAS-associated increases in morbidity and decreases in measles-specific antibody concentrations before and after vaccination. These findings support the evidence on PFAS immunotoxicity at comparatively low serum concentrations. https://doi.org/10.1289/EHP6517.
- Subjects :
- Male
medicine.medical_specialty
Health, Toxicology and Mutagenesis
010501 environmental sciences
Antibodies, Viral
01 natural sciences
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Internal medicine
Humans
Medicine
Guinea-Bissau
030212 general & internal medicine
Child
0105 earth and related environmental sciences
Fluorocarbons
Vaccines
business.industry
Extramural
Research
Vaccination
Public Health, Environmental and Occupational Health
Infant
Environmental Exposure
Guinea bissau
Child, Preschool
Cohort
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum perfluoroalkyl substances, vaccine responses, and morbidity in a cohort of guinea-bissau children ', Environmental Health Perspectives, vol. 128, no. 8, pp. 087002 . https://doi.org/10.1289/EHP6517, Environmental Health Perspectives, Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children ', Environmental Health Perspectives, vol. 128, no. 8, 087002 . https://doi.org/10.1289/EHP6517, Timmermann, C A G, Jensen, K J, Nielsen, F, Budtz-Jørgensen, E, van der Klis, F, Benn, C S, Grandjean, P & Fisker, A B 2020, ' Serum perfluoroalkyl substances, vaccine responses, and morbidity in a cohort of guinea-bissau children ', Environmental Health Perspectives, vol. 128, no. 8, 087002 . https://doi.org/10.1289/EHP6517
- Accession number :
- edsair.doi.dedup.....218fdc69fa6d7d535839022e42f05eac