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The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
- Source :
- Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and cellular landscape of the aging human lung. By intersecting these age-associated changes with experimental data on SARS-CoV-2, we identify several factors that may contribute to the heightened severity of COVID-19 in older populations. The aging lung is transcriptionally characterized by increased cell adhesion and stress responses, with reduced mitochondria and cellular replication. Deconvolution analysis reveals that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decrease with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21+ dendritic cells increase with age. Several age-associated genes directly interact with the SARS-CoV-2 proteome. Age-associated genes are also dysregulated by SARS-CoV-2 infection in vitro and in patients with severe COVID-19. These analyses illuminate avenues for further studies on the relationship between age and COVID-19.<br />Age is one of the strongest risk factors for severe illness from COVID-19. By integrating human lung transcriptomes with experimental data on SARS-CoV-2, the authors pinpoint specific age-associated factors that could contribute to the heightened severity of COVID-19 in older populations.
- Subjects :
- Adult
Male
0301 basic medicine
Aging
Science
Gene Expression
General Physics and Astronomy
macromolecular substances
Mitochondrion
Biology
medicine.disease_cause
Article
General Biochemistry, Genetics and Molecular Biology
Transcriptome
Young Adult
03 medical and health sciences
0302 clinical medicine
Gene expression
Immunogenetics
medicine
Humans
RNA-Seq
Cell adhesion
Lung
Aged
Coronavirus
A549 cell
Multidisciplinary
SARS-CoV-2
COVID-19
Endothelial Cells
General Chemistry
Fibroblasts
Middle Aged
respiratory system
In vitro
Cell biology
body regions
030104 developmental biology
medicine.anatomical_structure
Viral infection
A549 Cells
Data integration
Female
Pericytes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....218807afab9a13e1e55de7348d400413