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The Characterization of Low Renin Hypertension by Plasma Renin Activity and Plasma Aldosterone Concentration*
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 46:189-195
- Publication Year :
- 1978
- Publisher :
- The Endocrine Society, 1978.
-
Abstract
- Low renin hypertension (LRH) is characterized by suppression of plasma reninactivity (PRA) in the absence of demonstrable hypersecretion of aldosterone. We have investigated the dynamics of PRA and plasma aldosterone (PA) in 10 normal subjects and 12 LRHpatients during 6 h of upright posture on both normal and low sodium diets. Angiotensin Irecovery experiments excluded an inhibitor of either angiotensin I generation or binding to specific antibody which could account for low PRA. LRH patients could be divided into two groups on the basis of their PRA response to sodium depletion and upright posture. Those patients whose PRA never exceeded 3.0 ng/ml/h were assigned to group I. Those whose PRA achieved this level at any time were assigned togroup II. Whereas PRA and PA levels were lower in both group I and group II patients thanin the normal subjects, the ratio ofPA to PRA was consistently higher in LRH group I patients than in normal subjects; this ratio was not significantly different from normal in grou...
- Subjects :
- Adult
medicine.medical_specialty
animal structures
Endocrinology, Diabetes and Metabolism
food.diet
Sodium
Clinical Biochemistry
chemistry.chemical_element
Low sodium diet
urologic and male genital diseases
Biochemistry
Plasma renin activity
chemistry.chemical_compound
Endocrinology
food
Internal medicine
Renin
Renin–angiotensin system
medicine
Humans
Aldosterone
Aged
biology
Chemistry
Biochemistry (medical)
Diet, Sodium-Restricted
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Hypertension
biology.protein
Hypernatremia
Antibody
Hyponatremia
Mathematics
hormones, hormone substitutes, and hormone antagonists
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....2187aadfdfc1732989aa87a20219f757