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High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
- Source :
- Scientific reports, 11(1):18946. Nature Publishing Group, Scientific Reports, 11, Scientific Reports, Scientific Reports, 11, 1, Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports, 11:18946. Nature Publishing Group
- Publication Year :
- 2021
-
Abstract
- Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels result in reduction of VC. VSMC-derived EVs are assumed to be responsible for OPG transport and VC but this role has not been studied. For this, we investigated the association between OPG in plasma and circulating EVs with coronary artery calcium (CAC) as surrogate for VC in symptomatic patients. We retrospectively assessed 742 patients undergoing myocardial perfusion imaging (MPI). CAC scores were determined on the MPI-CT images using a previously developed automated algorithm. Levels of OPG were quantified in plasma and two EV-subpopulations (LDL and TEX), using an electrochemiluminescence immunoassay. Circulating levels of OPG were independently associated with CAC scores in plasma; OR 1.39 (95% CI 1.17–1.65), and both EV populations; EV-LDL; OR 1.51 (95% CI 1.27–1.80) and EV-TEX; OR 1.21 (95% CI 1.02–1.42). High levels of OPG in plasma were independently associated with CAC scores in this symptomatic patient cohort. High levels of EV-derived OPG showed the same positive association with CAC scores, suggesting that EV-derived OPG mirrors the same pathophysiological process as plasma OPG.
- Subjects :
- Male
Vascular smooth muscle
Coronary Artery Disease
Gastroenterology
Imaging
Prognostic markers
Risk Factors
Prospective Studies
education.field_of_study
Multidisciplinary
medicine.diagnostic_test
Myocardial Perfusion Imaging
Syndrome
Middle Aged
Coronary Vessels
Pathophysiology
Cohort
Isolation, separation and purification
Medicine
Female
Animal studies
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
musculoskeletal diseases
medicine.medical_specialty
Science
Population
Proteomic analysis
Predictive markers
Risk Assessment
Article
Extracellular Vesicles
Myocardial perfusion imaging
All institutes and research themes of the Radboud University Medical Center
Osteoprotegerin
Internal medicine
medicine
Humans
Vascular Calcification
education
Aged
Retrospective Studies
business.industry
Cardiovascular biology
Coronary artery calcification
Chronic Disease
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific reports, 11(1):18946. Nature Publishing Group, Scientific Reports, 11, Scientific Reports, Scientific Reports, 11, 1, Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports, 11:18946. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....2184ef900cfc9d4b64121b911e993be9