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Prediction of pathogenicity islands in enterohemorrhagic Escherichia coli O157:H7 using genomic barcodes
- Source :
- FEBS letters. 584(1)
- Publication Year :
- 2009
-
Abstract
- The genome of lethal animal pathogenic bacterium Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is characterized by the presence of multiple pathogenicity islands (PAIs). Computational methods have been developed to identify PAIs based on the distinguishing G+C levels in some PAI versus non-PAI regions. We observed that PAIs can have a very similar G+C level to that of the host chromosome, which may have led to false negative predictions using these methods. We have applied a novel method of genomic barcodes to identify PAIs. Using this technique, we have successfully identified both known and novel PAIs in the genomes of three strains of EHEC O157:H7.
- Subjects :
- Genomic Islands
Sequence analysis
Genomic barcode
Biophysics
Biology
medicine.disease_cause
Escherichia coli O157
Biochemistry
Genome
Microbiology
Bacterial genetics
03 medical and health sciences
Structural Biology
Host chromosome
Escherichia coli
Genetics
medicine
Molecular Biology
030304 developmental biology
EHEC O157:H7
0303 health sciences
Base Composition
030306 microbiology
Cell Biology
Genomics
Sequence Analysis, DNA
Chromosomes, Bacterial
biology.organism_classification
Pathogenicity island
3. Good health
Bacteria
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 584
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....2184173bc86cd3803b3b63e1a26f9aeb