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Outer Retinal Dysfunction on Multifocal Electroretinography May Help Differentiating Multiple Sclerosis From Neuromyelitis Optica Spectrum Disorder
- Source :
- Frontiers in Neurology, Frontiers in Neurology, Vol 10 (2019)
- Publication Year :
- 2019
-
Abstract
- Purpose: To evaluate the intermediate and outer retina of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using OCT and multifocal electroretinography (mf-ERG).Methods: Patients with MS (n = 30), NMOSD (n = 30), and healthy controls (n = 29) underwent visual field (VF), OCT, and mf-ERG testing. The eyes were distributed into 5 groups: MS with or without history of ON (MS+ON, MS–ON), NMOSD with or without ON (NMOSD+ON, NMOSD–ON), and controls. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was measured. mf-ERG P1 and N1 responses were registered and grouped in 3 sets of rings. The groups were compared using GEE models, and effect size (ES) calculated.Results: Compared to controls, GCL and IPL thickness was significantly smaller in MS+ON (both p < 0.01), MS–ON (p < 0.01 and p = 0.015, respectively), NMOSD+ON (both p < 0.01) and NMOSD–ON (p = 0.03 and p = 0.018, respectively). ES was >0.80. mRNFL was smaller in three of the above groups (p < 0.01, p < 0.001, and p = 0.028; ES > 0.80) but not in MS–ON eyes (p = 0.18). No significant difference was observed for the remaining layers. Compared to controls, P1 and N1 peak times were shorter in MS (p-values in the range 0.049–0.002, ES < 0.50; and 0.049–0.010; ES < 0.50, respectively) but not in NMOSD. These abnormalities were strongly correlated with intermediate and outer retinal layer thickness.Conclusions: mf-ERG data suggest outer retinal abnormalities in MS, but not in NMOSD. Our results may help understand how the two conditions differ regarding retinal damage.
- Subjects :
- medicine.medical_specialty
genetic structures
electroretinogram
Nerve fiber layer
Outer plexiform layer
neuromyelitis optica
multiple sclerosis
lcsh:RC346-429
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ophthalmology
Medicine
Outer nuclear layer
Ganglion cell layer
lcsh:Neurology. Diseases of the nervous system
Retina
optical coherence tomography
Neuromyelitis optica
business.industry
General Commentary
Retinal
retinal layers
Inner plexiform layer
medicine.disease
electrophysiology
eye diseases
bipolar cell
medicine.anatomical_structure
chemistry
Neurology
030221 ophthalmology & optometry
sense organs
Neurology (clinical)
multifocal electroretinogram
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16642295
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in neurology
- Accession number :
- edsair.doi.dedup.....218338877fd71629060e51703cbc0323