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Pivotal role of animal models in the development of new therapies for cytomegalovirus infections
- Source :
- Antiviral Research. 71:164-171
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Since human cytomegalovirus (CMV) is extremely species specific and does not replicate in experimental animal tissues, animal models for the evaluation of antiviral agents for these infections have utilized surrogate animal viruses including murine CMV, rat CMV and guinea pig CMV. Murine CMV and rat CMV infections in normal and immunocompromised animals provide models of disseminated infection and are ideal for screening of new agents. While guinea pig CMV infection in immunocompromised animals also provides a model for disseminated disease, the model for congenital CMV is unique among all the experimental models. While these models have played a major role in the development of ganciclovir, foscarnet and cidofovir, they do not provide information directly related to human CMV, nor are they useful for evaluation of agents that are active only against human CMV. The SCID-hu mouse models in which human tissue is infected with human CMV has been very useful in the development of new antiviral agents such as maribavir and cyclopropavir. Collectively these experimental CMV infections provide a variety of models representing various aspects of CMV infection in humans that are highly predictive for antiviral efficacy in humans.
- Subjects :
- Ganciclovir
Human cytomegalovirus
Foscarnet
Guinea Pigs
Cytomegalovirus
Mice, SCID
medicine.disease_cause
Antiviral Agents
Herpesviridae
Mice
chemistry.chemical_compound
Betaherpesvirinae
Virology
medicine
Animals
Humans
Pharmacology
biology
virus diseases
Maribavir
biology.organism_classification
medicine.disease
Rats
Disease Models, Animal
chemistry
Cytomegalovirus Infections
Immunology
medicine.drug
Cidofovir
Subjects
Details
- ISSN :
- 01663542
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Antiviral Research
- Accession number :
- edsair.doi.dedup.....217ca7150834c6189443faa6a1ea2e93