Back to Search
Start Over
Control of body temperature and immune function in patients undergoing open surgery for gastric cancer
- Source :
- Bosnian Journal of Basic Medical Sciences, Vol 18, Iss 3 (2018)
- Publication Year :
- 2018
- Publisher :
- Association of Basic Medical Sciences of FBIH, 2018.
-
Abstract
- The influence of mild perioperative hypothermia on the immune function and incidence of postoperative wound infections has been suggested, but the specific mechanism is unclear. This study aimed to analyze the body temperature, immune function, and wound infection rates in patients receiving open surgery for gastric cancer. Body temperature was controlled in each patient using one of four different methods: wrapping limbs, head and neck; insulated blankets; warming infusion fluids and insulated blankets; and warming fluids without insulated blankets. One hundred patients were randomly divided into four groups of 25 patients each, and every group received a different intraoperative treatment for maintaining normal body temperature. Nasopharyngeal and rectal temperatures, transforming growth factor beta (TGF-β), interleukin 10 (IL-10) levels, and cluster of differentiation (CD)3+T and CD4+/CD25+ regulatory T cell (Treg) counts were measured before surgery and at 2 and 4 hours postoperatively. Patients were evaluated at one week after surgery for signs of infection. Intraoperative body temperature and measures of immune function varied significantly between the four groups, with the largest temperature changes observed in the group in which only the limbs were wrapped in cotton pads to control the body temperature. The lowest temperature change (i.e., close to normal temperature) and cytokine response after surgery were observed in the group in which infusion fluids and transfused blood (if needed) were heated to 37℃, peritoneal irrigation fluid was heated to 37℃, and an insulation blanket was heated to 39℃ and placed under the patient. No intergroup differences were found in the infection rates at one week after surgery. In conclusion, body temperature variation during surgery affects the immune function of patients, and maintaining body temperature close to normal results in the least variation of immune function.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
TGF-β
CD4 CD25 Treg
CD3 Complex
Regulatory T cell
perioperative period
Body Temperature
03 medical and health sciences
0302 clinical medicine
Immune system
Stomach Neoplasms
Transforming Growth Factor beta
030202 anesthesiology
medicine
Humans
Postoperative Period
IL-2 receptor
Human body temperature
Aged
Aged, 80 and over
lcsh:R5-920
business.industry
Interleukin-2 Receptor alpha Subunit
Cancer
General Medicine
Perioperative
Middle Aged
Hypothermia
medicine.disease
heating methods
infection
Interleukin-10
Interleukin 10
medicine.anatomical_structure
Surgical Procedures, Operative
030220 oncology & carcinogenesis
Anesthesia
Female
medicine.symptom
Gastric cancer
lcsh:Medicine (General)
business
Research Article
Subjects
Details
- ISSN :
- 18404812 and 15128601
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Bosnian Journal of Basic Medical Sciences
- Accession number :
- edsair.doi.dedup.....216e69fc02742291b1714d0db4d2af43