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Adenosine receptors in COPD and asymptomatic smokers: effects of smoking cessation
- Source :
- Virchows Archiv, 454(3), 273-281. SPRINGER
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Our group has shown that 1-year smoking cessation persisted or increased airway inflammation in chronic obstructive pulmonary disease (COPD). We compared adenosine and adenosine receptor (AR) expression in COPD and asymptomatic smokers (AS) before and after 1-year smoking cessation. Sputum cytospins and bronchial biopsies of (ex)smoking COPD patients and AS were studied for A(1)R, A(2A)R, A(2B)R, and A(3)R expression. Adenosine and inflammatory mediators were measured in sputum supernatants. At baseline, COPD patients had lower levels of adenosine and higher levels of vascular endothelial growth factor in sputum than AS. Smoking cessation induced significantly different effects in COPD than in AS, i.e. an increase in percentages of A(3)R expressing neutrophils and A(1)R expressing macrophages in COPD as increase in adenosine and monocyte chemoattractant protein-1 levels in sputum. Adenosine-related effector mechanisms may contribute to the persistence and progression of airway inflammation in COPD following 1-year smoking cessation.
- Subjects :
- Adult
Male
Adenosine
AIRWAY INFLAMMATION
medicine.medical_treatment
Smoking cessation
LUNG HEALTH
OBSTRUCTIVE PULMONARY-DISEASE
Asymptomatic
BRONCHOALVEOLAR LAVAGE
RESPONSIVENESS
Pathology and Forensic Medicine
Pulmonary Disease, Chronic Obstructive
Bronchoscopy
medicine
Humans
COPD
Adenosine receptors
BRONCHITIS-TYPE
5'-MONOPHOSPHATE
Molecular Biology
Chromatography, High Pressure Liquid
Asthma
Inflammation
business.industry
Smoking
Respiratory disease
Receptors, Purinergic P1
Sputum
Cell Biology
General Medicine
Middle Aged
medicine.disease
Adenosine receptor
respiratory tract diseases
ENDOTHELIAL GROWTH-FACTOR
Immunology
Disease Progression
ASTHMA
Female
Inflammation Mediators
medicine.symptom
business
INTERVENTION
medicine.drug
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 454
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....2164b54a1368867d0715df300a401e28