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Group B Streptococcus surface proteins as major determinants for meningeal tropism
- Source :
- Current Opinion in Microbiology, Current Opinion in Microbiology, 2016, 15 (1), pp.44-49. ⟨10.1016/j.mib.2011.12.002⟩, Current Opinion in Microbiology, Elsevier, 2016, 15 (1), pp.44-49. ⟨10.1016/j.mib.2011.12.002⟩, Current Opinion in Microbiology, Elsevier, 2016, 15 (1), pp.44-49. 〈10.1016/j.mib.2011.12.002〉
- Publication Year :
- 2011
-
Abstract
- International audience; Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.
- Subjects :
- Microbiology (medical)
Virulence Factors
Clone (cell biology)
Biology
[ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
medicine.disease_cause
Streptococcus agalactiae/growth & development
Microbiology
Tropism
Group B
Neonatal meningitis
Streptococcus agalactiae
03 medical and health sciences
Meninges
Blood-Brain Barrier/microbiology
medicine
Humans
Membrane Proteins/metabolism
030304 developmental biology
0303 health sciences
030306 microbiology
Streptococcus
Membrane Proteins
INFECTIOUS PROCESS
medicine.disease
Virology
Streptococcus agalactiae/pathogenicity
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Virulence Factors/metabolism
3. Good health
Infectious Diseases
Blood-Brain Barrier
Meninges/microbiology
Subjects
Details
- ISSN :
- 18790364 and 13695274
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Current opinion in microbiology
- Accession number :
- edsair.doi.dedup.....2160152d5dd7e2da76f92f0f6ae2e28f