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Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children
- Source :
- Brain and language. 150
- Publication Year :
- 2014
-
Abstract
- Childhood apraxia of speech (CAS) is a neurogenic Speech Sound Disorder whose etiology and neurobiological correlates are still unclear. In the present study, 32 Italian children with idiopathic CAS underwent a comprehensive speech and language, genetic and neuroradiological investigation aimed to gather information on the possible behavioral and neurobiological markers of the disorder. The results revealed four main aggregations of behavioral symptoms that indicate a multi-deficit disorder involving both motor-speech and language competence. Six children presented with chromosomal alterations. The familial aggregation rate for speech and language difficulties and the male to female ratio were both very high in the whole sample, supporting the hypothesis that genetic factors make substantial contribution to the risk of CAS. As expected in accordance with the diagnosis of idiopathic CAS, conventional MRI did not reveal macrostructural pathogenic neuroanatomical abnormalities, suggesting that CAS may be due to brain microstructural alterations.
- Subjects :
- Male
Linguistics and Language
medicine.medical_specialty
Maximum performance task
Chromosomal Alterations
Apraxias
Cognitive Neuroscience
Experimental and Cognitive Psychology
Audiology
Speech Sound Disorder
Language and Linguistics
Childhood apraxia of speech
Developmental psychology
Speech and Hearing
Neurobiology
medicine
Humans
Speech
Genetic Predisposition to Disease
Child
Chromosome Aberrations
Infant, Newborn
Family aggregation
Infant
medicine.disease
Infant newborn
Magnetic Resonance Imaging
Array-Comparative Genomic Hybridization
Linguistic competence
Italy
Child, Preschool
Speech sound disorder
Language disorders
Etiology
Speech Sound Disorders
Female
Magnetic resonance imaging
3616
Male to female
Psychology
Subjects
Details
- ISSN :
- 10902155
- Volume :
- 150
- Database :
- OpenAIRE
- Journal :
- Brain and language
- Accession number :
- edsair.doi.dedup.....215d25435353f45f23b3424f05dc193a