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Changes in beta and high-gamma power in resting-state electrocorticogram induced by repetitive transcranial magnetic stimulation of primary motor cortex in unanesthetized macaque monkeys
- Source :
- Neuroscience research. 171
- Publication Year :
- 2021
-
Abstract
- Repetitive transcranial magnetic stimulation (rTMS) is now widely used as a means of neuromodulation, but the details of the mechanisms by which rTMS works remain unclarified. As a step forward to unveiling the neural phenomena occurring underneath the TMS coil, we conducted an electrophysiological study using awake and unanesthetized monkeys with subdural electrocorticogram (ECoG) electrodes implanted over the primary motor cortex (MI). We evaluated the effects of low-frequency (1 Hz) and high-frequency (10 Hz) rTMS on the resting-state ECoG signals in the stimulated MI, as well as the motor evoked potentials (MEPs) in the contralateral hand. Following the 1-Hz rTMS application, the ECoG beta band power and the MEP amplitude were significantly decreased. Following the 10-Hz rTMS application, the ECoG high-gamma power and the MEP amplitude significantly increased. Given that beta and high-gamma activities in the ECoG reflect the synchronous firing and the firing frequency of cell assemblies, respectively, in local neural circuits, these results suggest that low-frequency rTMS inhibits neural activity by desynchronizing the firing activity of local circuits, whereas high-frequency rTMS facilitates neural activity by increasing the firing rate of cell assemblies in the local circuits.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
behavioral disciplines and activities
Macaque
03 medical and health sciences
0302 clinical medicine
10007 Department of Economics
biology.animal
Repetitive transcranial magnetic stimulation (rTMS)
Biological neural network
Medicine
Animals
resting
state electrocorticogram (ECoG)
Beta (finance)
biology
Resting state fMRI
gamma power
business.industry
musculoskeletal, neural, and ocular physiology
General Neuroscience
motor evoked potential (MEP)
Motor Cortex
2800 General Neuroscience
General Medicine
Evoked Potentials, Motor
macaque monkey
Transcranial Magnetic Stimulation
Neuromodulation (medicine)
330 Economics
Transcranial magnetic stimulation
Electrophysiology
030104 developmental biology
nervous system
Macaca
beta powerHigh
Primary motor cortex
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18728111
- Volume :
- 171
- Database :
- OpenAIRE
- Journal :
- Neuroscience research
- Accession number :
- edsair.doi.dedup.....215a4075f96bc08732447eca04380fff