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Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals
- Source :
- The Journal of infectious diseases. 215(8)
- Publication Year :
- 2016
-
Abstract
- Background The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease. Methods We trialed a novel macrophage-specific arterial imaging technique. Results We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status. Conclusion These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV. Clinical trials registration NCT02542371.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Single Photon Emission Computed Tomography Computed Tomography
HIV Infections
Receptors, Cell Surface
Disease
030204 cardiovascular system & hematology
Mannans
03 medical and health sciences
0302 clinical medicine
In vivo
Medical imaging
medicine
Immunology and Allergy
Macrophage
Humans
Lectins, C-Type
030212 general & internal medicine
Aorta
medicine.diagnostic_test
business.industry
Macrophages
Brief Report
Colocalization
Dextrans
Middle Aged
Atherosclerosis
Plaque, Atherosclerotic
United States
Clinical trial
Infectious Diseases
Cross-Sectional Studies
Mannose-Binding Lectins
Case-Control Studies
Regression Analysis
Technetium Tc 99m Pentetate
Lymph Nodes
Radiopharmaceuticals
business
Ex vivo
Emission computed tomography
Mannose Receptor
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 215
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....2151ccc830e4a65aea64f6571798fd8f