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N ‐chlorotaurine, a potent weapon against multiresistant bacteria
- Source :
- Journal of Applied Microbiology
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Aims N‐chlorotaurine (NCT) is a body‐own mild oxidizing antiseptic that can be applied topically as a well‐tolerated anti‐infective at many body sites. The objective of this study was to demonstrate its activity against representative nosocomial multidrug‐resistant bacteria. Methods and Results The bactericidal activity of NCT was tested in quantitative killing assays against a panel of multiresistant Gram‐positive and Gram‐negative clinical isolates. N‐chlorotaurine (1%, 55 mmol l−1) reduced the number of CFU of strains of methicillin‐resistant Staphylococcus aureus, linezolid‐resistant Staphylococcus epidermidis, vancomycin‐resistant, and linezolid‐ and vancomycin‐resistant Enterococcus faecium, 3MRGN and 4MRGN Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae by at least 2 log10 steps after 15 min and completely or nearly to the detection limit after 30 min at pH 7·1 and 37°C. Conclusion The activity of NCT against these clinical isolates is similar to that against non‐resistant ATCC strains and therefore not influenced by antibiotic resistance. This can be explained by the oxidizing and chlorinating mechanism of action of NCT, which leads to an attack of multiple targets in the microorganisms. Significance and Impact of the Study The bactericidal spectrum of NCT is not restricted by resistance against antibiotics. Therefore, it can be used against resistant strains, too.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Taurine
medicine.drug_class
N‐chlorotaurine
Antibiotics
Microbial Sensitivity Tests
medicine.disease_cause
Applied Microbiology and Biotechnology
Microbiology
resistance
03 medical and health sciences
chemistry.chemical_compound
Antibiotic resistance
Staphylococcus epidermidis
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria
medicine
Antimicrobials/Disinfection/Sterilization
chloramines
030304 developmental biology
0303 health sciences
biology
030306 microbiology
Pseudomonas aeruginosa
Original Articles
General Medicine
biology.organism_classification
Anti-Bacterial Agents
Acinetobacter baumannii
chemistry
multiresistant bacteria
Staphylococcus aureus
antiseptic
Linezolid
Original Article
anti‐infective
Biotechnology
Enterococcus faecium
Subjects
Details
- ISSN :
- 13652672 and 13645072
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Microbiology
- Accession number :
- edsair.doi.dedup.....214dba925fd32a005aa3023f43732534