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Potential clinical applications of microRNAs as biomarkers of renal cell carcinoma
- Source :
- Central European Journal of Urology
- Publication Year :
- 2018
- Publisher :
- Polish Urological Association, 2018.
-
Abstract
- Introduction Renal cell carcinoma (RCC) accounts for 3% of adult malignancies and more than 90% of kidney neoplasms. High rates of undiagnostic percutaneous kidney biopsies and difficulties in reliable pre-operative differentiation between malignant and benign renal tumors using contemporary imaging techniques result in large numbers of redundant surgeries. Absence of specific biomarkers for early detection and monitoring complicates on-time diagnosis of the disease and relapse. For the patients followed up after having a nephrectomy, a noninvasive and sensitive biomarker enabling early detection of disease relapse would be extremely useful. Material and methods The study is a review of recent knowledge regarding potential clinical applications of microRNAs (miRNAs) as biomarkers of RCC. Results MicroRNAs are essential regulators of various processes such as cell proliferation, differentiation, development and death; they have been implicated in diverse biological and pathological processes in RCC. There is a class of miRNAs that promote RCC development (oncomirs) and a class of miRNAs that negatively regulate oncogenes, suppress tumor growth and invasion, and thus could be considered treatment agents (anti-oncomirs). Separate miRNAs and specific miRNAs expression profiles have been identified, enabling early detection of the disease, prediction of response to systemic therapy, or prognostication of biological behavior of the disease. Conclusions The miRNA network analysis and gene profiling may help to identify the most sensible molecular signatures of RCC that can be used for diagnostic purposes, as well as poor prognosis signatures and poor therapeutic response signatures in patients who undergo systemic therapy.
- Subjects :
- 0301 basic medicine
renal cell carcinoma
medicine.medical_treatment
Disease
03 medical and health sciences
0302 clinical medicine
Renal cell carcinoma
microRNA
diagnostics
medicine
Pathological
Review Paper
Kidney
Cell growth
business.industry
prediction
General Medicine
medicine.disease
Nephrectomy
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
biomarker
Biomarker (medicine)
prognosis
business
Subjects
Details
- ISSN :
- 20804873
- Database :
- OpenAIRE
- Journal :
- Central European Journal of Urology
- Accession number :
- edsair.doi.dedup.....212714397de6d0537ea0a7b1bbd06081