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Carotid intima-media thickness is reduced 12months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance
- Source :
- Journal of Diabetes and its Complications. 28:517-522
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT).Observational prospective study, 34 obese patients (T2D (n = 14)/IGT (n = 4), and NGT (n = 16)) were investigated before and six and 12months after RYGB.Mean carotid IMT was significantly reduced 12months after RYGB in patients with T2D/IGT (-0.041 mm (95% CI -0.069; -0.012, p = 0.005)) but not in patients with NGT (-0.010 mm (-0.039; 0.020, p = 0.52)). The between-group difference was not significant (p=0.13). Twelve months after RYGB, patients with respectively T2D/IGT and NGT demonstrated changes in weight: -29.9 kg, p0.001/-30.6 kg, p0.001, HbA1c: -0.7%, p0.001/-0.1%, p = 0.33, systolic blood pressure: -2 mmHg, p = 0.68/-10 mmHg, p = 0.01 and diastolic blood pressure: -8 mmHg, p = 0.003/-11 mmHg, p0.001. 80% of T2D patients terminated antihyperglycaemic medication.Mean carotid IMT was significantly reduced 12months after RYGB in patients with T2D/IGT which provides evidence to support that the earliest atherosclerotic changes in the arterial wall are reversible. Although numerically different from the changes observed in patients with NGT, the between-group difference was not statistically significant.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Adolescent
endocrine system diseases
Denmark
Endocrinology, Diabetes and Metabolism
Gastric Bypass
Down-Regulation
Type 2 diabetes
medicine.disease_cause
Carotid Intima-Media Thickness
Gastroenterology
Body Mass Index
Impaired glucose tolerance
Young Adult
Endocrinology
Risk Factors
Internal medicine
Diabetes mellitus
Glucose Intolerance
Weight Loss
Internal Medicine
medicine
Humans
In patient
Vascular Diseases
Prospective cohort study
Glycated Hemoglobin
Normal glucose tolerance
business.industry
Gastric bypass surgery
nutritional and metabolic diseases
Middle Aged
medicine.disease
Obesity, Morbid
Diabetes Mellitus, Type 2
Intima-media thickness
Hyperglycemia
Hypertension
Female
business
Diabetic Angiopathies
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 10568727
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes and its Complications
- Accession number :
- edsair.doi.dedup.....2121d13bc3a63e1904f0302be939b95e