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Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels
- Source :
- Pediatric Surgery International. 27:263-268
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival.To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up. Note that, in the field of organ transplantation, transplants are categorized as incompatible, compatible or identical; accordingly, these are the terms we use in the paper.A clinical outpatient study measuring serum transforming growth factor (TGF)-β1, interferon (IFN)-γ, interleukin (IL)-2 and IL-10 in 43 living related liver transplantation (LRLT) recipients, of whom 36 received ABO-c LRLT (34 were ABO-identical and 2 were non-identical) and 7 ABO-i LRLT. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase and bilirubin were measured as part of the patients' regular follow-up visits.There were no differences between the ABO-c and ABO-i groups in terms of recipient's age [mean 12.6 vs. 11.1 years (y)], post-LTx duration (mean 7.3 vs. 7.3 y), donor's age (mean 35.5 vs. 34.6 y), body weight (28.9 ± 2.9 vs. 27.9 ± 6.9 kg), or gender (19 female and 17 male vs. 4 female and 3 male). Serum TGF-β1, IFN-γ and IL-2 were significantly higher in the ABO-i group than in the ABO-c group. IL-10, however, did not differ between the two groups. There was a tendency toward higher γGTP levels in the ABO-i group, but this difference did not reach significance.ABO-incompatible LRLTx patients have higher serum TGF-β1, IFN-γ and IL-2 levels as measured at regular outpatient visits. As a result, they face a higher risk of T-helper 1 cell polarization, which could make graft rejection more likely.
- Subjects :
- Male
Interleukin 2
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Liver transplantation
Statistics, Nonparametric
Organ transplantation
ABO Blood-Group System
Transforming Growth Factor beta1
Interferon-gamma
Young Adult
Liver Function Tests
hemic and lymphatic diseases
ABO blood group system
parasitic diseases
Living Donors
Humans
Medicine
Young adult
Child
medicine.diagnostic_test
business.industry
Graft Survival
Infant
General Medicine
biological factors
Liver Transplantation
surgical procedures, operative
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
Interleukin-2
Female
Surgery
Graft survival
business
Liver function tests
medicine.drug
Transforming growth factor
Subjects
Details
- ISSN :
- 14379813 and 01790358
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Pediatric Surgery International
- Accession number :
- edsair.doi.dedup.....211f8453e4c5cab9ffbc28d1ccec88f9