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Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis: A multi-institutional study
- Source :
- Gynecologic Oncology. 153:13-19
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients.Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome.Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P 0.0001) and overall survival (P 0.0001) were poorer in patients with GAS than in those with UEA.GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA.UMIN Clinical Trials Registry: UMIN000007987.
- Subjects :
- Adult
0301 basic medicine
Oncology
medicine.medical_specialty
Uterine Cervical Neoplasms
Stromal Invasion
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Mucinous carcinoma
Papillomaviridae
Pathological
Aged
Neoplasm Staging
business.industry
Papillomavirus Infections
Obstetrics and Gynecology
Middle Aged
Institutional review board
medicine.disease
Adenocarcinoma, Mucinous
Progression-Free Survival
Lymphovascular
Survival Rate
Clinical trial
030104 developmental biology
030220 oncology & carcinogenesis
T-stage
Population study
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 153
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....211492170330359672e5b5218c32fed9