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Tunable functionalization of nano-emulsions using amphiphilic polymers
- Source :
- Soft Matter, Soft Matter, Royal Society of Chemistry, 2020, ⟨10.1039/D0SM01952F⟩
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- Nano-emulsions are defined as stable oil droplets sizing below 300 nm. Their singular particularity lies in the loading capabilities of their oily core, much higher than other kinds of carrier. On the other hand, functionalizing the dynamic oil/water interface, to date, has remained a challenge. To ensure the best anchoring of the reactive functions onto the surface of the droplets, we have designed specific amphiphilic polymers (APs) based on poly(maleic anhydride-alt-1-octadecene), stabilizing the nano-emulsions instead of surfactants. Aliphatic C18 chains of the APs are anchored in the droplet core, while the hydrophilic parts of the APs are poly(ethylene glycol) (PEG) chains. In addition, PEG chains are terminated with reactive (i) azide functions in order to prove the concept of the droplet decoration with clickable rhodamine (Rh-DBCO, specifically synthesized for this study), or (ii) biotin functions to verify the potential droplet functionalization with fluorescent streptavidin (streptavidin-AF-488). This study describes AP synthesis, physico-chemical characterization of the functional droplets (electron microscopy), and finally fluorescence labeling and droplet decoration. To conclude, these APs constitute an interesting solution for the stable functionalization of nano-emulsion droplets, paving a new way for the applications of nano-emulsions in targeting drug delivery.
- Subjects :
- Streptavidin
Materials science
Polymers
02 engineering and technology
010402 general chemistry
01 natural sciences
Polyethylene Glycols
Rhodamine
Surface-Active Agents
chemistry.chemical_compound
PEG ratio
ComputingMilieux_MISCELLANEOUS
[CHIM.ORGA]Chemical Sciences/Organic chemistry
technology, industry, and agriculture
[CHIM.MATE]Chemical Sciences/Material chemistry
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
eye diseases
0104 chemical sciences
chemistry
Chemical engineering
Oil droplet
Drug delivery
Surface modification
Emulsions
Azide
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Ethylene glycol
Subjects
Details
- ISSN :
- 17446848 and 1744683X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Soft Matter
- Accession number :
- edsair.doi.dedup.....2113aeb79c1ae598a2d758ae53c09afc