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A trans-ancestral meta-analysis of Genome-wide Association Studies reveals loci associated with childhood obesity
- Source :
- Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Helgeland, Ø, Horikoshi, M, Karhunen, V, Lowry, E, Cousminer, D L, Ahluwalia, T S, Thiering, E, Boh, E T, Zafarmand, M H, Vilor-tejedor, N, Wang, C A, Joro, R, Chen, Z, Gauderman, W J, Pitkänen, N, Parra, E J, Fernandez-rhodes, L, Alyass, A, Monnereau, C, Curtin, J A, Have, C T, Mccormack, S E, Hollensted, M, Frithioff-bøjsøe, C, Valladares-salgado, A, Peralta-romero, J, Teo, Y, Standl, M, Leinonen, J T, Holm, J, Peters, T, Vioque, J, Vrijheid, M, Simpson, A, Custovic, A, Vaudel, M, Canouil, M, Lindi, V, Atalay, M, Kähönen, M, Raitakari, O T, Van Schaik, B D C, Berkowitz, R I, Cole, S A, Voruganti, V S, Wang, Y, Highland, H M, Comuzzie, A G, Butte, N F, Justice, A E, Gahagan, S, Blanco, E, Lehtimäki, T, Lakka, T A, Hebebrand, J, Bonnefond, A, Grarup, N, Froguel, P, Lyytikäinen, L, Cruz, M, Kobes, S, Hanson, R L, Zemel, B S, Hinney, A, Teo, K K, Meyre, D, North, K E, Gilliland, F D, Bisgaard, H, Bustamante, M, Bonnelykke, K, Pennell, C E, Rivadeneira, F, Uitterlinden, A G, Baier, L J, Vrijkotte, T G M, Heinrich, J, Sørensen, T I A, Saw, S, Pedersen, O, Hansen, T, Eriksson, J, Widén, E, Mccarthy, M I, Njølstad, P R, Power, C, Hyppönen, E, Sebert, S, Brown, C D, Järvelin, M, Timpson, N J, Johansson, S, Hakonarson, H, Jaddoe, V W V & Grant, S F A 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Hum. Mol. Genet. 28, 3327-3338 (2019), Lowry, E 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Human Molecular Genetics, HUMAN MOLECULAR GENETICS, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Hum Mol Genet, Human Molecular Genetics, 28(19), 3327-3338. Oxford University Press, Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Helgeland, O, Horikoshi, M, Karhunen, V, Lowry, E, Cousminer, D L, Ahluwalia, T S, Thiering, E, Boh, E T-H, Zafarmand, M H, Vilor-Tejedor, N, Wang, C A, Joro, R, Chen, Z, Gauderman, W J, Pitkanen, N, Parra, E J, Fernandez-Rhodes, L, Alyass, A, Monnereau, C, Curtin, J A, Have, C T, McCormack, S E, Hollensted, M, Frithioff-Bojsoe, C, Valladares-Salgado, A, Peralta-Romero, J, Teo, Y-Y, Standl, M, Leinonen, J T, Holm, J-C, Peters, T, Vioque, J, Vrijheid, M, Simpson, A, Custovic, A, Vaudel, M, Canouil, M, Lindi, V, Atalay, M, Kahonen, M, Raitakari, O T, van Schaik, B D C, Berkowitz, R I, Cole, S A, Voruganti, V S, Wang, Y, Highland, H M, Comuzzie, A G, Butte, N F, Justice, A E, Gahagan, S, Blanco, E, Lehtimaki, T, Lakka, T A, Hebebrand, J, Bonnefond, A, Grarup, N, Froguel, P, Lyytikainen, L-P, Cruz, M, Kobes, S, Hanson, R L, Zemel, B S, Hinney, A, Teo, K K, Meyre, D, North, K E, Gilliland, F D, Bisgaard, H, Bustamante, M, Bønnelykke, K, Pennell, C E, Rivadeneira, F, Uitterlinden, A G, Baier, L J, Vrijkotte, T G M, Heinrich, J, Sorensen, T I A, Saw, S-M, Pedersen, O, Hansen, T, Eriksson, J, Widen, E, McCarthy, M I, Njolstad, P R, Power, C, Hypponen, E, Sebert, S, Brown, C D, Jarvelin, M-R, Timpson, N J, Johansson, S, Hakonarson, H, Jaddoe, V W V & Grant, S F A 2019, ' A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity ', Human Molecular Genetics, vol. 28, no. 19, pp. 3327-3338 . https://doi.org/10.1093/hmg/ddz161, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Timpson, N & al., E 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Human molecular genetics, 28(19), 3327-3338. Oxford University Press, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2–18 years old) and 15 599 controls (consistently
- Subjects :
- Male
obesity
Pediatric Obesity
Medizin
IDENTIFIES 3
Genome-wide association study
VARIANTS
ethnic group
single nucleotide polymorphism
genetics
bayesian analysis
genes
Association Studies Article
Child
Genetics (clinical)
11 Medical and Health Sciences
2. Zero hunger
Genetics
Genetics & Heredity
child
0303 health sciences
adult
030305 genetics & heredity
1184 Genetics, developmental biology, physiology
Chromosome Mapping
General Medicine
3. Good health
Female
body mass index procedure
childhood obesity
Life Sciences & Biomedicine
asian
Biochemistry & Molecular Biology
SUSCEPTIBILITY LOCI
DATABASE
Single-nucleotide polymorphism
Locus (genetics)
Biology
Polymorphism, Single Nucleotide
Wilms Tumor
Childhood obesity
03 medical and health sciences
SDG 3 - Good Health and Well-being
Genetic variation
medicine
MANAGEMENT
Humans
Genetic Predisposition to Disease
genome
Molecular Biology
030304 developmental biology
genome-wide association study
Science & Technology
Early Growth Genetics Consortium
Case-control study
Bayes Theorem
06 Biological Sciences
medicine.disease
Obesity
MC3R GENE
Genetic Loci
Case-Control Studies
1182 Biochemistry, cell and molecular biology
Body mass index
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 09646906
- Database :
- OpenAIRE
- Journal :
- Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Helgeland, Ø, Horikoshi, M, Karhunen, V, Lowry, E, Cousminer, D L, Ahluwalia, T S, Thiering, E, Boh, E T, Zafarmand, M H, Vilor-tejedor, N, Wang, C A, Joro, R, Chen, Z, Gauderman, W J, Pitkänen, N, Parra, E J, Fernandez-rhodes, L, Alyass, A, Monnereau, C, Curtin, J A, Have, C T, Mccormack, S E, Hollensted, M, Frithioff-bøjsøe, C, Valladares-salgado, A, Peralta-romero, J, Teo, Y, Standl, M, Leinonen, J T, Holm, J, Peters, T, Vioque, J, Vrijheid, M, Simpson, A, Custovic, A, Vaudel, M, Canouil, M, Lindi, V, Atalay, M, Kähönen, M, Raitakari, O T, Van Schaik, B D C, Berkowitz, R I, Cole, S A, Voruganti, V S, Wang, Y, Highland, H M, Comuzzie, A G, Butte, N F, Justice, A E, Gahagan, S, Blanco, E, Lehtimäki, T, Lakka, T A, Hebebrand, J, Bonnefond, A, Grarup, N, Froguel, P, Lyytikäinen, L, Cruz, M, Kobes, S, Hanson, R L, Zemel, B S, Hinney, A, Teo, K K, Meyre, D, North, K E, Gilliland, F D, Bisgaard, H, Bustamante, M, Bonnelykke, K, Pennell, C E, Rivadeneira, F, Uitterlinden, A G, Baier, L J, Vrijkotte, T G M, Heinrich, J, Sørensen, T I A, Saw, S, Pedersen, O, Hansen, T, Eriksson, J, Widén, E, Mccarthy, M I, Njølstad, P R, Power, C, Hyppönen, E, Sebert, S, Brown, C D, Järvelin, M, Timpson, N J, Johansson, S, Hakonarson, H, Jaddoe, V W V & Grant, S F A 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Hum. Mol. Genet. 28, 3327-3338 (2019), Lowry, E 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Human Molecular Genetics, HUMAN MOLECULAR GENETICS, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Hum Mol Genet, Human Molecular Genetics, 28(19), 3327-3338. Oxford University Press, Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Helgeland, O, Horikoshi, M, Karhunen, V, Lowry, E, Cousminer, D L, Ahluwalia, T S, Thiering, E, Boh, E T-H, Zafarmand, M H, Vilor-Tejedor, N, Wang, C A, Joro, R, Chen, Z, Gauderman, W J, Pitkanen, N, Parra, E J, Fernandez-Rhodes, L, Alyass, A, Monnereau, C, Curtin, J A, Have, C T, McCormack, S E, Hollensted, M, Frithioff-Bojsoe, C, Valladares-Salgado, A, Peralta-Romero, J, Teo, Y-Y, Standl, M, Leinonen, J T, Holm, J-C, Peters, T, Vioque, J, Vrijheid, M, Simpson, A, Custovic, A, Vaudel, M, Canouil, M, Lindi, V, Atalay, M, Kahonen, M, Raitakari, O T, van Schaik, B D C, Berkowitz, R I, Cole, S A, Voruganti, V S, Wang, Y, Highland, H M, Comuzzie, A G, Butte, N F, Justice, A E, Gahagan, S, Blanco, E, Lehtimaki, T, Lakka, T A, Hebebrand, J, Bonnefond, A, Grarup, N, Froguel, P, Lyytikainen, L-P, Cruz, M, Kobes, S, Hanson, R L, Zemel, B S, Hinney, A, Teo, K K, Meyre, D, North, K E, Gilliland, F D, Bisgaard, H, Bustamante, M, Bønnelykke, K, Pennell, C E, Rivadeneira, F, Uitterlinden, A G, Baier, L J, Vrijkotte, T G M, Heinrich, J, Sorensen, T I A, Saw, S-M, Pedersen, O, Hansen, T, Eriksson, J, Widen, E, McCarthy, M I, Njolstad, P R, Power, C, Hypponen, E, Sebert, S, Brown, C D, Jarvelin, M-R, Timpson, N J, Johansson, S, Hakonarson, H, Jaddoe, V W V & Grant, S F A 2019, ' A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity ', Human Molecular Genetics, vol. 28, no. 19, pp. 3327-3338 . https://doi.org/10.1093/hmg/ddz161, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Bradfield, J P, Vogelezang, S, Felix, J F, Chesi, A, Timpson, N & al., E 2019, ' A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz161, Human molecular genetics, 28(19), 3327-3338. Oxford University Press, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Accession number :
- edsair.doi.dedup.....21089d4557dc1ac98012520f3fd35847