Back to Search
Start Over
Volumetric and texture analysis on FDG PET in evaluating and predicting treatment response and recurrence after chemotherapy in follicular lymphoma
- Source :
- International Journal of Clinical Oncology. 24:1292-1300
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The purpose of this study was to determine if quantitative SUV-related, volumetric FDG PET parameters, and texture features (SPs, VPs, and TFs, respectively) were useful to evaluate and predict response and recurrence after chemotherapy in follicular lymphoma (FL). Pre- and posttreatment FDG PET examinations in 45 FL patients were analyzed retrospectively. In addition to SPs in the representative lesion, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated as VPs for the representative and whole-body lesions. Six TFs were calculated in the pretreatment representative lesion. Response results with reduction of SPs or VPs after treatment (Δ) were compared to the Lugano classification based on visual assessment. SPs, VPs, and Δ of them as well as TFs were also evaluated if they allow prediction of response and recurrence after chemotherapy. Quantitative assessment with SPs and VPs provided 89% and 93–96% concordant results, respectively, with Lugano classification. Among pretreatment PET parameters, low gray-level zone emphasis (LGZE) in TFs solely showed statistical significance to predict complete response. All of posttreatment and Δ of SPs and VPs were considered as the predictors of progression free survival in the univariate Cox regression analysis, but none of them was the predictor in the multivariate analysis. This study demonstrated that quantitative PET parameters were applicable to evaluate treatment response in FL. Texture analysis showed promise in predicting treatment response. Although posttreatment and Δ of PET parameters were the candidates, all of them proved to have limited value in predicting recurrence after chemotherapy.
- Subjects :
- Adult
Male
0301 basic medicine
Multivariate analysis
medicine.medical_treatment
Follicular lymphoma
Lesion
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Surgical oncology
Statistical significance
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Progression-free survival
Lymphoma, Follicular
Aged
Retrospective Studies
Aged, 80 and over
Chemotherapy
business.industry
Proportional hazards model
fungi
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Tumor Burden
030104 developmental biology
Oncology
Positron-Emission Tomography
030220 oncology & carcinogenesis
Female
Surgery
Neoplasm Recurrence, Local
Radiopharmaceuticals
medicine.symptom
Nuclear medicine
business
Subjects
Details
- ISSN :
- 14377772 and 13419625
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....21031d42f6c00f9a013d9c197c03b8f8