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The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2020
-
Abstract
- Bone metabolic disorders include osteolysis, osteoporosis, osteoarthritis and rheumatoid arthritis. Osteoblasts and osteoclasts are two major types of cells in bone constituting homeostasis. The imbalance between bone formation by osteoblasts and bone resorption by osteoclasts has been shown to have a direct contribution to the onset of these diseases. Recent evidence indicates that autophagy and mitophagy, the selective autophagy of mitochondria, may play a vital role in regulating the proliferation, differentiation and function of osteoblasts and osteoclasts. Several signaling pathways, including PINK1/Parkin, SIRT1, MAPK8/FOXO3, Beclin-1/BECN1, p62/SQSTM1, and mTOR pathways, have been implied in the regulation of autophagy and mitophagy in these cells. Here we review the current progress about the regulation of autophagy and mitophagy in osteoblasts and osteoclasts in these bone metabolic disorders, as well as the molecular signaling activated or deactivated during this process. Together, we hope to draw attention to the role of autophagy and mitophagy in bone metabolic disorders, and their potential as a new target for the treatment of bone metabolic diseases and the requirements of further mechanism studies.
- Subjects :
- musculoskeletal diseases
autophagy
Osteolysis
Osteoclasts
PINK1
Review
Biology
Applied Microbiology and Biotechnology
Bone resorption
Arthritis, Rheumatoid
03 medical and health sciences
Osteoclast
Mitophagy
Osteoarthritis
medicine
Animals
Humans
Molecular Biology
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
Osteoblasts
Autophagy
bone metabolic disorder
Osteoblast
Cell Biology
BECN1
medicine.disease
Cell biology
medicine.anatomical_structure
osteoclast
osteoblast
Osteoporosis
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 14492288
- Volume :
- 16
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- International journal of biological sciences
- Accession number :
- edsair.doi.dedup.....20fee1bed0fc87aa889e20a7fe64e48f