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C21orf57 is a human homologue of bacterial YbeY proteins
- Source :
- PMC
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.<br />National Institutes of Health (U.S.) (Grant GM31010)<br />National Institutes of Health (U.S.) (Grant GM17151)
- Subjects :
- 0301 basic medicine
Chloroplasts
RNase P
Molecular Sequence Data
030106 microbiology
Saccharomyces cerevisiae
Mutant
Biophysics
medicine.disease_cause
Biochemistry
Article
Evolution, Molecular
03 medical and health sciences
Ribonucleases
Metalloproteins
medicine
Amino Acid Sequence
Molecular Biology
Escherichia coli
Gene
Conserved Sequence
Genetics
Base Sequence
Sequence Homology, Amino Acid
biology
Escherichia coli Proteins
Cell Biology
biology.organism_classification
Phenotype
030104 developmental biology
Function (biology)
Bacteria
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 484
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....20f04c19f5e1fe6b8dab161325aa61c2