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WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice
- Source :
- BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-9 (2018), BMC Pulmonary Medicine
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca2+ overload and neutrophil infiltration, have been implied in the pathogenesis of liver and remote organ injuries following reperfusion. WNT1 inducible signaling pathway protein 1 (WISP1) is an extracellular matrix protein that has been associated with the onset of several malignant diseases. Previous work in our group has demonstrated WISP1 is upregulated and contributes to proinflammatory cascades in hepatic IRI. However, the role of WISP1 in the pathogenesis of lung injury after hepatic IRI still remains unknown. Methods Male C57BL/6 mice were used to examine the expression and role of WISP1 in the pathogenesis of lung injuries after hepatic IRI and explore its potential mechanisms in mediating lung injuries. Results We found WISP1 was upregulated in lung tissues following hepatic IRI. Treatment with anti-WISP1 antibody ameliorated lung injuries with alteration of cytokine profiles. Administration with rWISP1 aggravated lung injuries following hepatic IRI through excessive production of proinflammatory cytokines and inhibition of anti-inflammatory cytokines. Conclusions In this study, we concluded that WISP1 contributed to lung injuries following hepatic IRI through TLR4 pathway.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
medicine.medical_treatment
WNT1 inducible signaling pathway protein 1
Lung injury
medicine.disease_cause
Toll like receptor
Proinflammatory cytokine
CCN Intercellular Signaling Proteins
Pathogenesis
Mice
03 medical and health sciences
Inflammatory cascades
Proto-Oncogene Proteins
Hepatic ischemia-reperfusion injury
medicine
Animals
lcsh:RC705-779
Lung
WNT1-inducible-signaling pathway protein 1
business.industry
Lung Injury
lcsh:Diseases of the respiratory system
Up-Regulation
Mice, Inbred C57BL
Toll-Like Receptor 4
Oxidative Stress
030104 developmental biology
Cytokine
medicine.anatomical_structure
Liver
Neutrophil Infiltration
Reperfusion Injury
TLR4
Cytokines
business
Oxidative stress
Signal Transduction
Research Article
Subjects
Details
- ISSN :
- 14712466
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....20ed565e2c8071b01db22640012c0ac1