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Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
- Source :
- Nutrition Journal
- Publication Year :
- 2014
-
Abstract
- Background Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption. Objective The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins. Methods Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months. Results No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12:p = 0.045; week 24:p = 0.039) and routine (week 12:p = 0.031; week 24:p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p
- Subjects :
- Dietary Fiber
Male
Fat soluble vitamins
030309 nutrition & dietetics
Medicine (miscellaneous)
Blood lipids
Tocopherols
030204 cardiovascular system & hematology
Portfolio diet
chemistry.chemical_compound
0302 clinical medicine
Lycopene
Hyperlipidemia
Nuts
Single-Blind Method
Food science
Vitamin A
0303 health sciences
Nutrition and Dietetics
Retinol
Phytosterols
Vitamins
Middle Aged
beta Carotene
3. Good health
Cholesterol
Biochemistry
Intestinal cholesterol absorption
lipids (amino acids, peptides, and proteins)
Female
Adult
Canada
Campesterol
education
Hyperlipidemias
Clinical nutrition
Plant sterols
03 medical and health sciences
medicine
Humans
Triglycerides
business.industry
Research
Cholesterol, HDL
Lutein
Cholesterol, LDL
Feeding Behavior
medicine.disease
Carotenoids
Sitosterols
Diet
Fat-Soluble Vitamin
chemistry
business
Follow-Up Studies
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nutrition Journal
- Accession number :
- edsair.doi.dedup.....20eabad99ea6c5130277fd8d1c397ae2