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The Impact of Imatinib on Survival and Treatment Trends for Small Bowel and Colorectal Gastrointestinal Stromal Tumors
- Source :
- Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(1)
- Publication Year :
- 2019
-
Abstract
- The aim of this study is to assess treatment trends and overall survival (OS) in small bowel (SB) and colorectal (CR) gastrointestinal stromal tumors (GIST) with respect to the introduction of imatinib in 2008. Patients diagnosed with SB and CR GIST were identified from the National Cancer Database (2004–2015). The primary outcome was 5- and 10-year OS. Patients were stratified by tumor site, time period (before and after imatinib), and treatment type. OS was analyzed using Kaplan-Meier survival curves, log-rank test, and Cox proportional hazards models. A total of 8441 cases were included (SB 81.66%; CR 18.34%). Radical resection was the most common treatment (SB 42.33%; CR 38.69%). The addition of chemotherapy to radical resection for SB GIST increased between the two time periods (31.76 to 40.43%; p
- Subjects :
- Male
medicine.medical_specialty
Stromal cell
Databases, Factual
Gastrointestinal Stromal Tumors
medicine.medical_treatment
Antineoplastic Agents
Kaplan-Meier Estimate
030230 surgery
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Intestine, Small
medicine
Humans
Survival analysis
Aged
Gastrointestinal Neoplasms
Retrospective Studies
Chemotherapy
GiST
Tumor size
Proportional hazards model
business.industry
Cancer
Imatinib
Middle Aged
medicine.disease
digestive system diseases
United States
030220 oncology & carcinogenesis
Imatinib Mesylate
Surgery
Female
business
Colorectal Neoplasms
medicine.drug
Subjects
Details
- ISSN :
- 18734626
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
- Accession number :
- edsair.doi.dedup.....20dfb25026ab52dd54459e6151262175