Back to Search
Start Over
In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy
- Source :
- Lasers in Medical Science. 33:609-617
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- This research work mainly deals with studying qualitatively the changes in the dermal collagen of two forms of striae distensae (SD) namely striae rubrae (SR) and striae albae (SA) when compared to normal skin (NS) using confocal Raman spectroscopy. The methodology includes an in vivo human skin study for the comparison of confocal Raman spectra of dermis region of SR, SA, and NS by supervised multivariate analysis using partial least squares discriminant analysis (PLS-DA) to determine qualitatively the changes in dermal collagen. These groups are further analyzed for the extent of hydration of dermal collagen by studying the changes in the water content bound to it. PLS-DA score plot showed good separation of the confocal Raman spectra of dermis region into SR, SA, and NS data groups. Further analysis using loading plot and S-plot indicated the participation of various components of dermal collagen in the separation of these groups. Bound water content analysis showed that the extent of hydration of collagen is more in SD when compared to NS. Based on the results obtained, this study confirms the active involvement of dermal collagen in the formation of SD. It also emphasizes the need to study quantitatively the role of these various biochemical changes in the dermal collagen responsible for the variance between SR, SA, and NS.
- Subjects :
- Adult
Confocal
Human skin
Dermatology
Spectrum Analysis, Raman
01 natural sciences
030207 dermatology & venereal diseases
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Dermis
In vivo
medicine
Humans
Striae distensae
Bound water
Least-Squares Analysis
integumentary system
Chemistry
010401 analytical chemistry
Discriminant Analysis
Water
medicine.disease
0104 chemical sciences
medicine.anatomical_structure
symbols
Biophysics
Female
Surgery
Collagen
Striae Distensae
Raman spectroscopy
Confocal raman spectroscopy
Subjects
Details
- ISSN :
- 1435604X and 02688921
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Lasers in Medical Science
- Accession number :
- edsair.doi.dedup.....20dd8e0a7a65868823383ab8cbeef315