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Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma
- Source :
- Annals of Surgical Oncology. 27:2033-2041
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based follow-up schedule. Utilizing a prospective database, a retrospective single center review was performed of all patients with minimum 2-year follow-up after resection of a localized extremity STS. Kaplan–Meier estimates were used to calculate the incidence of local recurrence and metastases on an annual basis for 10 years. We identified a total of 230 low-grade, 626 intermediate-grade and 940 high-grade extremity STS and a total of 721 events, 150 local recurrences and 571 metastases. Based on tumor size and grade, follow-up cohorts were developed that had similar metastatic risk. Using pre-determined thresholds for metastatic event, a follow-up schedule was established for each cohort. Based on our results we recommend that patients with small low-grade tumors undergo annual follow-up for 5 years following definitive local treatment. Patients with large low-grade tumors, small intermediate-grade and small high-grade tumors should have follow-up every 6 months for the first 2 years, then yearly to 10 years. Only patients with large intermediate- or high-grade tumors require follow-up every 3 months for the first 2 years, then every 6 months for years 3–5, followed by annually until 10 years.
- Subjects :
- Adult
Diagnostic Imaging
Male
medicine.medical_specialty
Time Factors
Kaplan-Meier Estimate
Single Center
Disease-Free Survival
Metastasis
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Surgical oncology
medicine
Humans
Neoplasm Metastasis
Aged
Retrospective Studies
Evidence-Based Medicine
business.industry
Incidence
Soft tissue sarcoma
Incidence (epidemiology)
Extremities
Sarcoma
Retrospective cohort study
Middle Aged
medicine.disease
Oncology
030220 oncology & carcinogenesis
Predictive value of tests
Cohort
Disease Progression
Female
030211 gastroenterology & hepatology
Surgery
Radiology
Neoplasm Grading
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....20d9489fca8c2c144d1c48edff0bf431