Back to Search
Start Over
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 20:526-530
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent (6) was prepared. High affinity LXR ligands were identified (LXRbeta binding IC(50) values
- Subjects :
- Agonist
Benzimidazole
medicine.drug_class
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Cell Line
Sulfone
Mice
Structure-Activity Relationship
chemistry.chemical_compound
Drug Discovery
polycyclic compounds
medicine
Animals
Humans
Potency
Structure–activity relationship
RNA, Messenger
Sulfones
Liver X receptor
Molecular Biology
Liver X Receptors
Chemistry
Organic Chemistry
Biological activity
Orphan Nuclear Receptors
Rats
Microsomes, Liver
Microsome
Molecular Medicine
ATP-Binding Cassette Transporters
Benzimidazoles
lipids (amino acids, peptides, and proteins)
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....20d60265884c5333d8090122fcf95248
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.11.099