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The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Source :
- Marine Drugs, Vol 19, Iss 265, p 265 (2021), Marine Drugs
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.
- Subjects :
- Drug
Cell cycle checkpoint
QH301-705.5
media_common.quotation_subject
Anti-Inflammatory Agents
Pharmaceutical Science
Antineoplastic Agents
Apoptosis
Review
brown algae
Fucose
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
fucoidan
Polysaccharides
Neoplasms
Drug Discovery
Animals
Humans
Medicine
Cytotoxic T cell
Tumor growth
Biology (General)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
030304 developmental biology
media_common
0303 health sciences
Fucoidan
business.industry
Cell Cycle
cytotoxic effects
anticancer activity
tumor growth
chemistry
030220 oncology & carcinogenesis
Cancer cell
Cancer research
business
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 265
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....20b1a19f8d0cc40e7dea58a0aac4536f