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Supplementary Figure 5 from Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- Supplementary Figure S5. Response to W+T treatment in the L858R/T790M EGFR genetically engineered mouse model (LT GEMM). (A) Immunohistochemical analysis LT GEMMs treated with two doses of WZ4002, trametinib or a combination thereof assessing phosphorylation of EGFR, AKT and ERK1/2 at 100 nM. (B) TUNEL staining analysis of LT GEMMs treated with two doses of WZ4002, trametinib or a combination thereof at the 50 and 100 nM. (C) Tumor volume of individual LT GEMMs treated with 50 mg/kg WZ4002, 2.5 mg/kg trametinib and the combination up to 20 weeks (13). (D) Representative MRI images from each treatment.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....20a839aff26ac99dd8951244b354c4d8