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The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study
- Source :
- Dementia and Geriatric Cognitive Disorders. 29:1-10
- Publication Year :
- 2010
- Publisher :
- S. Karger AG, 2010.
-
Abstract
- Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion.
- Subjects :
- Male
medicine.medical_specialty
Cognitive Neuroscience
Neuropsychological Tests
Single-photon emission computed tomography
Apraxia
Central nervous system disease
Executive Function
Degenerative disease
Radionuclide angiography
Alzheimer Disease
Internal medicine
medicine
Humans
Radionuclide Angiography
Aged
Retrospective Studies
Psychiatric Status Rating Scales
Tomography, Emission-Computed, Single-Photon
medicine.diagnostic_test
Depression
Brain
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
Cerebrovascular Circulation
Cardiology
Female
Geriatrics and Gerontology
Alzheimer's disease
Psychology
Perfusion
Neuroscience
Subjects
Details
- ISSN :
- 14219824 and 14208008
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Dementia and Geriatric Cognitive Disorders
- Accession number :
- edsair.doi.dedup.....2075ac4a083eda7e12ee608ea042637c