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Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up
- Source :
- American Heart Journal. 142:720-724
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- The epidemiologic data on heart failure are scarce. This study aimed at identifying predictors of left ventricular systolic dysfunction in a cohort of middle-aged men with a 20-year follow-up.A population-based cohort of 431 50-year-old men was examined with blood pressure and anthropometric measurements together with lipid, glucose, and insulin determinations. A reinvestigation 20 years later also included echocardiography, ambulatory blood pressure monitoring, hyperinsulinemic euglycemic clamp, and oral glucose tolerance test. Sixteen subjects were found to have left ventricular systolic dysfunction at age 70 years, defined as an ejection fraction/=0.40. A control group of 48 subjects matched on myocardial infarction, hypertension, diabetes, and use of cardiovascular medication, but with an ejection fraction0.40, was used in a nested case-control analysis.At age 50 years, heart rate (P.01), plasma proinsulin (P.05), and the proportion of dihomogammalinolenic acid in serum cholesterol esters (P.05) were increased and serum phosphate decreased (P.01) in the subjects identified with left ventricular systolic dysfunction at age 70 years compared with controls. No major metabolic abnormalities were associated with left ventricular systolic dysfunction at age 70 years compared with controls.Factors associated with insulin resistance precede left ventricular systolic dysfunction independently of ischemic heart disease and hypertension after 20 years of follow-up.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Ambulatory blood pressure
Heart disease
Cohort Studies
Ventricular Dysfunction, Left
Insulin resistance
Heart Rate
Risk Factors
Diabetes mellitus
Internal medicine
Humans
Medicine
Myocardial infarction
Aged
Metabolic Syndrome
Sweden
Ejection fraction
business.industry
Age Factors
Middle Aged
medicine.disease
Surgery
Glucose
Blood pressure
Echocardiography
Case-Control Studies
Heart failure
Cardiology
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Proinsulin
Subjects
Details
- ISSN :
- 00028703
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- American Heart Journal
- Accession number :
- edsair.doi.dedup.....20735a1b8fe77225bf1d62cca5ca2352