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Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
- Source :
- Journal of Medicinal Chemistry. 59:1727-1746
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.
- Subjects :
- Male
0301 basic medicine
Drug
media_common.quotation_subject
Drug Resistance
Pulmonary disease
Mice, Inbred Strains
Disease
Drug resistance
Pharmacology
Biology
Mice
Pulmonary Disease, Chronic Obstructive
Structure-Activity Relationship
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Animals
Humans
Protein Kinase Inhibitors
media_common
Asthma
COPD
Dose-Response Relationship, Drug
Molecular Structure
Drug discovery
Kinase
U937 Cells
medicine.disease
030104 developmental biology
030228 respiratory system
Molecular Medicine
Steroids
Protein Kinases
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....2066096c894114db7d281ae5538082d4