Back to Search Start Over

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

Authors :
Kazuhiro Ito
Alun John Smith
Catherine Elisabeth Charron
Garth Rapeport
Fritz Frickel
Stuart Thomas Onions
Marie Colucci
Andrew Novak
Peter Strong
Kevin Joly
George Hardy
P. John Murray
David Michel Adrien Taddei
Richard James Brown
Yasuo Kizawa
Anjna Rani
Ian Knowles
Jonathan Gareth Williams
John King-Underwood
Source :
Journal of Medicinal Chemistry. 59:1727-1746
Publication Year :
2016
Publisher :
American Chemical Society (ACS), 2016.

Abstract

The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.

Details

ISSN :
15204804 and 00222623
Volume :
59
Database :
OpenAIRE
Journal :
Journal of Medicinal Chemistry
Accession number :
edsair.doi.dedup.....2066096c894114db7d281ae5538082d4