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Anti-inflammatory Properties of an Oxidized Sterol
- Source :
- Journal of Investigative Dermatology. 84(2):126-129
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- A polar photoproduct of cholesterol oxidation, 7-ketocholesterol, was able to inhibit in a dose-dependent manner the mouse ear-swelling response to irritants such as croton oil or cantharidin. Its anti-inflammatory properties were much less than equivalent concentrations of hydrocortisone, but the oxidized sterol did not induce any systemic effects (as measured by thymolytic activity), as did topical hydrocortisone. It is concluded that 7-ketocholesterol has weak anti-inflammatory activity, and its mode of action may be different from that of glucocorticoids.
- Subjects :
- Hydrocortisone
Croton Oil
medicine.drug_class
Administration, Topical
Anti-Inflammatory Agents
Dermatology
Pharmacology
Topical hydrocortisone
Biochemistry
Anti-inflammatory
Mice
chemistry.chemical_compound
medicine
Animals
Croton oil
Mode of action
Ketocholesterols
Molecular Biology
Inflammation
Cantharidin
Dose-Response Relationship, Drug
Cholesterol
Cell Biology
Sterol
chemistry
Female
medicine.drug
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 84
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....2064ad98c2745808402e1348f52820f6
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12275361