Back to Search
Start Over
Modulation of Sodium Iodide Symporter in Thyroid Cancer
- Publication Year :
- 2014
-
Abstract
- Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient’s survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects. Sodium iodide symporter (NIS) mediates iodide influx, and NIS expression and function can be selectively enhanced in thyroid cells by thyroid-stimulating hormone. We summarize our current knowledge of NIS modulation in normal and cancer thyroid cells, and we propose that several reagents evaluated in clinical trials for other diseases can be used to restore or further increase RAI accumulation in thyroid cancer. Once validated in preclinical mouse models and clinical trials, these reagents, mostly small-molecule inhibitors, can be readily translated into clinical practice. We review available genetically engineered mouse models of thyroid cancer in terms of their tumor development and progression as well as their thyroid function. These mice will not only provide important insights into the mechanisms underlying the loss of RAI uptake in thyroid tumors but will also serve as preclinical animal models to evaluate the efficacy of candidate reagents to selectively increase RAI uptake in thyroid cancers. Taken together, we anticipate that the optimal use of RAI in the clinical management of thyroid cancer is yet to come in the near future.
- Subjects :
- Sodium-iodide symporter
Cancer Research
medicine.medical_specialty
endocrine system
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Drug Evaluation, Preclinical
Thyrotropin
Article
Papillary thyroid cancer
Iodine Radioisotopes
Mice
Endocrinology
Internal medicine
hemic and lymphatic diseases
medicine
Animals
Humans
Thyroid Neoplasms
Anaplastic thyroid cancer
Neoplasm Metastasis
Thyroid cancer
Clinical Trials as Topic
Symporters
Endocrine and Autonomic Systems
business.industry
Thyroid
Cancer
medicine.disease
Up-Regulation
Disease Models, Animal
medicine.anatomical_structure
Oncology
Cancer research
Thyroid function
business
Genetic Engineering
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....20616ed15571b694e02ee059a3f804c1