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Hypothalamo-pituitary-adrenal function in infantile spasms: effects of ACTH therapy
- Source :
- Journal of child neurology. 2(3)
- Publication Year :
- 1987
-
Abstract
- The metyrapone test was used to study the hypothalamo-pituitary-adrenal function in ten children with infantile spasms, before and after ACTH treatment. The hypothalamo-pituitary-adrenal response was normal before ACTH treatment in almost all children. After ACTH, the responses of two children were suggestive of a diminished pituitary reserve; three were suggestive of decreased adrenal as well as decreased pituitary reserve, and one suggested either adrenal hyperplasia with normal pituitary reserve, or appropriate response to a developing medical stress. We suggest that, in children being treated with ACTH, the dosage of ACTH should be gradually tapered, AM cortisol levels should be monitored, and high-dose steroids should be included when treating medical stress. ( J Child Neurol 1987;2:220-223).
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Hydrocortisone
Cortodoxone
Acth treatment
03 medical and health sciences
0302 clinical medicine
Adrenocorticotropic Hormone
030225 pediatrics
Internal medicine
medicine
Adrenal function
Humans
Cortisol level
Infant
Hyperplasia
Metyrapone
medicine.disease
Endocrinology
Pediatrics, Perinatology and Child Health
Metyrapone test
Female
Neurology (clinical)
Psychology
Spasms, Infantile
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08830738
- Volume :
- 2
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of child neurology
- Accession number :
- edsair.doi.dedup.....20605214500510d04c1cc737449b130d