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Antibodies to neuronal surface antigens in patients with a clinical diagnosis of neurodegenerative disorder
- Publication Year :
- 2021
-
Abstract
- Objectives Autoimmune encephalitis due to antibodies against neuronal surface antigens (NSA-Ab) frequently presents with cognitive impairment, often as the first and prevalent manifestation, but few studies have systematically assessed the frequency of NSA-Ab in consecutive patients with established neurodegenerative disorders. Methods We studied sera of 93 patients (41F, 52 M), aged 69.2 ± 9.4 years, with neurodegenerative conditions, and of 50 population controls aged over 60 years. Specific NSA-Abs were investigated by antigen-specific cell-based assays (CBAs). After testing, we evaluated the association between the NSA-Abs and clinical, CSF and radiological features. Results The patients included 13/93 (13.8%) who had specific antibodies to neuronal surface antigens: 6 GlyR, 3 GABAAR (1 also positive for AMPAR), 2 LGI1, 1 CASPR2 and 1 GABABR. One of the 50 controls (2%) was positive for NMDAR antibody and the others were negative on all tests (P = 0.020). No difference was observed in antibody frequency between patients presenting with parkinsonism and those presenting with dementia (P = 0.55); however, NSA-Ab were more frequent in those with unclassified forms of dementia (5/13, 38.5%) than in those with unclassified parkinsonism (2/9, 22.2%) or with classified forms of dementia (4/43, 9.3%) or parkinsonism (2/28, 7.1%) (P = 0.03). A logistic regression analysis demonstrated that an unclassified diagnosis (P = 0.02) and an irregular progression (P = 0.024) were predictors of seropositive status. Conclusions NSA-Abs are relatively frequent in patients with neurodegenerative disorders, particularly in those with an irregular disease progression of atypical clinical features, inconsistent with a recognized diagnosis. The significance of these antibodies and their possible primary or secondary roles need to be investigated in prospective studies.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Immunology
Population
Hashimoto Disease
Logistic regression
Gastroenterology
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Autoimmune encephaliti
Antigen
Internal medicine
Autoimmune dementia
Encephaliti
medicine
Dementia
Humans
Prospective Studies
Prospective cohort study
education
Autoantibodies
Autoimmune encephalitis
education.field_of_study
biology
Endocrine and Autonomic Systems
business.industry
Parkinsonism
Neurodegenerative Diseases
Neurodegenerative disorder
medicine.disease
Autoantibodie
Prospective Studie
030104 developmental biology
Neuronal surface antibodie
Antigens, Surface
biology.protein
Encephalitis
Antibody
business
030217 neurology & neurosurgery
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....205fea8b6c753b85091ed577ab01be3c