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Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning
- Source :
- Bioorganicmedicinal chemistry letters. 23(17)
- Publication Year :
- 2013
-
Abstract
- Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80 μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. © 2013 Elsevier Ltd. All rights reserved.
- Subjects :
- DNA, Bacterial
Methicillin-Resistant Staphylococcus aureus
Cell division
Membrane permeability
medicine.drug_class
Medicinal & Biomolecular Chemistry
Clinical Biochemistry
Antibiotics
Pharmaceutical Science
Biochemistry
Microbiology
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Humans
Spiro Compounds
Molecular Biology
biology
Chemistry
Alkaloid
Organic Chemistry
Chromosomes, Bacterial
Staphylococcal Infections
biology.organism_classification
Anti-Bacterial Agents
Porifera
Molecular Medicine
Tyrosine
Amine gas treating
Antibacterial activity
Bacteria
DNA
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 23
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....205ae6be61d606faebd8b5e3dbbfd876