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Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal–Maternal Interface and the Peripheral Blood
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 5 (2014)
- Publication Year :
- 2014
- Publisher :
- Frontiers Media S.A., 2014.
-
Abstract
- The human T cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known about repertoire composition at different anatomical sites. Here, we determine the T cell receptor beta variable (TRBV) repertoire at the decidua and compare it with the peripheral blood during normal pregnancy and pre-eclampsia. We found total T cell subset disparity of up to 58% between sites, including large signature TRBV expansions unique to the fetal–maternal interface. Defining the functional nature and specificity of compartment-specific T cells will be necessary if we are to understand localized immunity, tolerance, and pathogenesis.
- Subjects :
- lcsh:Immunologic diseases. Allergy
pre-eclampsia
T cell
Placenta
Immunology
Biology
CD8+ T cells
Flow cytometry
Pathogenesis
medicine
Immunology and Allergy
Cytotoxic T cell
Compartment (development)
T cell receptor (TCR)
Original Research
Fetus
decidual mononuclear cells
medicine.diagnostic_test
Repertoire
Decidua
Peripheral Blood
R1
CD4+ T cells
medicine.anatomical_structure
pregnancy
lcsh:RC581-607
T cell repertoire
Treg cells
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....205ad6c835800c82d581217bb59701f0
- Full Text :
- https://doi.org/10.3389/fimmu.2014.00033