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A New Potent Antimicrobial Metalloporphyrin

Authors :
Lu Jiang
Pei Lin Chee
Ching Ruey Raymond Gan
T. S. Andy Hor
Xian Jun Loh
Shan Jiang
Jian Gao
Rajamani Lakshminarayanan
Cally Owh
Source :
Chemistry – An Asian Journal. 16:1007-1015
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

A series of bis -acryl functionalized porphyrins and their corresponding metalloporphyrins (M = Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.

Details

ISSN :
1861471X and 18614728
Volume :
16
Database :
OpenAIRE
Journal :
Chemistry – An Asian Journal
Accession number :
edsair.doi.dedup.....20587b1acb420e0285e992ddbf5fea66
Full Text :
https://doi.org/10.1002/asia.202100053