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A New Potent Antimicrobial Metalloporphyrin
- Source :
- Chemistry – An Asian Journal. 16:1007-1015
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- A series of bis -acryl functionalized porphyrins and their corresponding metalloporphyrins (M = Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.
- Subjects :
- Staphylococcus aureus
Cell Survival
Metalloporphyrins
010402 general chemistry
Hemolysis
01 natural sciences
Biochemistry
chemistry.chemical_compound
Escherichia coli
Humans
Cytotoxicity
Cells, Cultured
Dose-Response Relationship, Drug
Molecular Structure
biology
010405 organic chemistry
Organic Chemistry
General Chemistry
biology.organism_classification
Antimicrobial
Porphyrin
Combinatorial chemistry
Anti-Bacterial Agents
0104 chemical sciences
Kinetics
chemistry
Bacteria
Subjects
Details
- ISSN :
- 1861471X and 18614728
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Chemistry – An Asian Journal
- Accession number :
- edsair.doi.dedup.....20587b1acb420e0285e992ddbf5fea66
- Full Text :
- https://doi.org/10.1002/asia.202100053