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Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution
- Source :
- Regulatory toxicology and pharmacology : RTP. 81
- Publication Year :
- 2016
-
Abstract
- Umbilical cord-derived mesenchymal stem cells (UC-MSCs) therapy might be an alternative to liver transplantation for acute or chronic liver injury. The aim of this study was to evaluate the efficacy of human UC-MSCs on carbon tetrachloride (CCl4)-induced acute liver injury. In addition, its toxicity, tumorigenicity, and biodistribution were determined. Significant hepatoprotective effects of hUC-MSCs with decreased levels of hepatocellular necrosis and lobular neutrophilic infiltration were found. Regarding the safety of hUC-MSCs, no serious hUC-MSCs-related changes (body weight, food/water consumption, clinical symptom, urinalysis, hematology, clinical chemistry, organ weight, and histopathology) were observed in a 13-week subchronic toxicity study. In a 26-week tumorigenicity study, no mice developed tumor related to hUC-MSCs transplantation up to 1 × 108 cells/kg. In particular, human mitochondrial sequence detection revealed that most hUC-MSCs were cleared from the major organs of the mice at 13 weeks after transplantation. There was no systemic toxicity or neoplastic finding either. Taken together, these results suggested that hUC-MSCs have great potential for future clinical treatment of acute liver disease.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Pathology
medicine.medical_treatment
Mice, Nude
Liver transplantation
Toxicology
Mesenchymal Stem Cell Transplantation
Umbilical cord
Umbilical Cord
03 medical and health sciences
Mice
Internal medicine
medicine
Animals
Humans
Carbon Tetrachloride
Liver injury
Mice, Inbred BALB C
Hematology
business.industry
Mesenchymal stem cell
Mesenchymal Stem Cells
General Medicine
Liver Failure, Acute
medicine.disease
Transplantation
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Toxicity
Histopathology
business
Subjects
Details
- ISSN :
- 10960295
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Regulatory toxicology and pharmacology : RTP
- Accession number :
- edsair.doi.dedup.....2056333c3d57ab9f4f9c6694a9e4316e